Drug
Dinutuximab
Drug Profile
| Therapeutic Class | Monoclonal Antibodies (mAbs) |
| Drug Class | Other mAbs |
| Group | anti-GD2 mAb |
| Mechanism of Action | Anti-GD2 antibody |
| Half-life | 10 d |
Study design
RT–Drug Timing Window
Study design
RT–Drug Timing Window
Radiobiological rationale for RT–drug interaction
Immunologically synergistic (RT-enhanced ADCC), not a DNA-level sensitizer (Cash et al., Journal of Clinical Oncology, 2025; Anderson et al., Clinical Cancer Research, 2022). The principal class adverse event is severe neuropathic pain and capillary-leak/hypersensitivity from the antibody itself; theoretical overlap of RT-induced inflammation with antibody-mediated inflammation could aggravate local reactions.
Data on this page refer exclusively to patients treated with
Dinutuximab combined with SBRT, without concurrent use of
drugs from other classes.
Combination therapy data and pooled group-level evidence are available on the
anti-GD2 mAb group page.