Source Articles
Tislelizumab
Showing 1 study arm
with grade ≥3 adverse event data (treatment-related and RT-related).
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Note on patient counts: some articles reported only percentages rather
than absolute numbers. Where this occurred, the number of patients — including those with
grade ≥3 adverse events — was derived by applying the reported percentage to the total arm
size, which may produce a non-integer value. These figures have been rounded to the nearest
integer for display.
| 1st Author | Year | Study Type | Title | DOI | clinical trial number | number of patients | median/mean age | tumor type | treatment setting | drug group | drug name | if other, please specify | number of SBRT courses | intracranial / extracranial | treated site | If other treated site, please specify | median/mean total RT dose [Gy] | minimum total RT dose [Gy] | maximum total RT dose [Gy] | median/mean number of fractions | minimum number of fractions | maximum number of fractions | median/mean dose per fraction [Gy] | minimum dose per fraction [Gy] | maximum dose per fraction [Gy] | toxicity type | patients with acute G>=3 toxicity | patients with late G>=3 toxicity | patients with G>=3 toxicity, timing unspecified | G>=3 AEs | patients with G>=3 AEs | details on G>=3 toxicity | details on G>=3 toxicity in RT field |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Li et al. | 2024 | Prospective | Neoadjuvant tislelizumab plus stereotactic body radiotherapy and adjuvant tislelizumab in early-stage resectable hepatocellular carcinoma: the Notable-HCC phase 1b trial | 10.1038/s41467-024-47420-3 | NCT05185531 | 20 | 58.5 | HCC | primary | Anti-PD-(L)1 mAb | Tislelizumab | — | 20 | extra-cranial | liver | — | 24 | 24 | 24 | 3 | 3 | 3 | 8 | 8 | 8 | Treatment-rel. | — | — | 8 | any G3: 8 AE | any G3: 8 pt | any G3: Lymphocyte count decrease, platelet count decrease, white blood cell decrease, aspartate aminotransferase increase, neutrophil count decrease, alanine aminotransferase increase | — |