Drug
Pertuzumab
Drug Profile
| Therapeutic Class | Monoclonal Antibodies (mAbs) |
| Drug Class | HER2-Targeting |
| Group | anti-HER2 mAb |
| Mechanism of Action | Anti-HER2 antibody |
| Half-life | 18 d |
Study design
RT–Drug Timing Window
Study design
RT–Drug Timing Window
Radiobiological rationale for RT–drug interaction
Radiosensitizing in HER2-overexpressing tumors (↓PI3K/AKT, impaired repair, ↓hypoxia) (Liang et al., Molecular Cancer Therapeutics, 2003; Pietras et al., Cancer Research, 1999; Song et al., Cancers, 2022). Because activity is antigen-restricted to HER2-overexpressing tumor cells, the theoretical normal-tissue sensitization—and thus added in-field side-effects—is low.
Data on this page refer exclusively to patients treated with
Pertuzumab combined with SBRT, without concurrent use of
drugs from other classes.
Combination therapy data and pooled group-level evidence are available on the
anti-HER2 mAb group page.